Stimulation of MMP-9 of oral epithelial cells by areca nut extract is related to TGF-ß/Smad2-dependent and -independent pathways and prevented by betel leaf extract, hydroxychavicol and melatonin.

Chang, Mei-Chi; Pan, Yu-Hwa; Wu, Hsyueh-Liang; Lu, Yi-Jie; Liao, Wan-Chuen; Yeh, Chien-Yang; Lee, Jang-Jaer; Jeng, Jiiang-Huei

Chang, Mei-Chi; Pan, Yu-Hwa; Wu, Hsyueh-Liang; Lu, Yi-Jie; Liao, Wan-Chuen; Yeh, Chien-Yang; Lee, Jang-Jaer; Jeng, Jiiang-Huei.

Afiliación

Chang MC; Chang-Gung University of Science and Technology, Kwei-Shan, Taoyuan, Taiwan.
Pan YH; Department of Dentistry, Chang Gung Memorial Hospital, Taipei, Taiwan.
Wu HL; Department of Dentistry, Chang Gung Memorial Hospital, Taipei, Taiwan.
Lu YJ; Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan.
Liao WC; Graduate Institute of Oral Biology, National Taiwan University Medical College, Taipei, Taiwan.
Yeh CY; School of Dentistry, National Taiwan University Medical College, and Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan.
Lee JJ; School of Dentistry, National Taiwan University Medical College, and Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan.
Jeng JH; School of Dentistry, National Taiwan University Medical College, and Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan.

Aging (Albany NY) ; 11(23): 11624-11639, 2019 12 12.

Article en En | MEDLINE | ID: mdl-31831717

Asunto(s)

Areca; Células Epiteliales/efectos de los fármacos; Metaloproteinasa 9 de la Matriz/metabolismo; Extractos Vegetales/farmacología; Proteína Smad2/metabolismo; Factor de Crecimiento Transformador beta/metabolismo; Arecolina/farmacología; Línea Celular Tumoral; Supervivencia Celular/efectos de los fármacos; Células Epiteliales/metabolismo; Eugenol/análogos & derivados; Eugenol/farmacología; Regulación de la Expresión Génica/efectos de los fármacos; Humanos; Metaloproteinasa 9 de la Matriz/genética; Melatonina/farmacología; Extractos Vegetales/química; Hojas de la Planta/química; Proteína Smad2/genética; Factor de Crecimiento Transformador beta/genética

Palabras clave

MMP-9; areca nut; betel leaf; hydroxychavicol; oral cancer

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Areca / Extractos Vegetales / Factor de Crecimiento Transformador beta / Metaloproteinasa 9 de la Matriz / Células Epiteliales / Proteína Smad2 Límite: Humans Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2019 Tipo del documento: Article País de afiliación: Taiwán

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