Exploring Multicompartment Plug Flow-Based Model Approach in Biopharmaceutics: Impact of Stomach Setting and the Estimation of the Fraction Absorbed of Orally Administered Basic Drugs.

Chiang, Po-Chang; Nagapudi, Karthik; Dolton, Michael J; Liu, Jia

Chiang, Po-Chang; Nagapudi, Karthik; Dolton, Michael J; Liu, Jia.

Afiliación

Chiang PC; Genentech Research and Development, SMPS, Genentech, 1 DNA Way, South San Francisco, California 94080. Electronic address: Chiang.pochang@gene.com.
Nagapudi K; Genentech Research and Development, SMPS, Genentech, 1 DNA Way, South San Francisco, California 94080.
Dolton MJ; Clinical Pharmacology, Genentech, 1 DNA Way, South San Francisco, California 94080.
Liu J; Genentech Research and Development, SMPS, Genentech, 1 DNA Way, South San Francisco, California 94080.

J Pharm Sci ; 109(3): 1261-1269, 2020 03.

Article en En | MEDLINE | ID: mdl-31836377

Asunto(s)

Biofarmacia; Preparaciones Farmacéuticas; Administración Oral; Humanos; Absorción Intestinal; Modelos Biológicos; Solubilidad; Estómago

Palabras clave

Fa; absorption; absorption efficiency; false-negative; fraction absorbed; modeling; pharmacokinetics; physiological; solubilization; stomach

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Biofarmacia / Preparaciones Farmacéuticas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Pharm Sci Año: 2020 Tipo del documento: Article

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