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Peste des petits ruminants pathogenesis on experimental infected goats by the Moroccan 2015 isolate.
Bamouh, Z; Fakri, F; Jazouli, M; Safini, N; Omari Tadlaoui, K; Elharrak, M.
Afiliación
  • Bamouh Z; Research and Development, MCI Santé Animale, Lot. 157, Z. I., Sud-Ouest (ERAC) B.P: 278, 28810, Mohammedia, Morocco. z.bamouh@mci-santeanimale.com.
  • Fakri F; Research and Development, MCI Santé Animale, Lot. 157, Z. I., Sud-Ouest (ERAC) B.P: 278, 28810, Mohammedia, Morocco.
  • Jazouli M; Research and Development, MCI Santé Animale, Lot. 157, Z. I., Sud-Ouest (ERAC) B.P: 278, 28810, Mohammedia, Morocco.
  • Safini N; Research and Development, MCI Santé Animale, Lot. 157, Z. I., Sud-Ouest (ERAC) B.P: 278, 28810, Mohammedia, Morocco.
  • Omari Tadlaoui K; Research and Development, MCI Santé Animale, Lot. 157, Z. I., Sud-Ouest (ERAC) B.P: 278, 28810, Mohammedia, Morocco.
  • Elharrak M; Research and Development, MCI Santé Animale, Lot. 157, Z. I., Sud-Ouest (ERAC) B.P: 278, 28810, Mohammedia, Morocco.
BMC Vet Res ; 15(1): 452, 2019 Dec 16.
Article en En | MEDLINE | ID: mdl-31842890
BACKGROUND: Peste des petits ruminants (PPR) is a viral disease of major economic importance on small ruminants. Goats are usually known to be more susceptible to the disease. Infection chronology, virus circulation, and the disease early detection need to be better understood. This study evaluates the tissue tropism and pathogenesis of PPR following experimental infection of goats using a lineage IV virus, the most dominant in the world originated from Asia. PPRV infection was experimentally induced in 4 six-month-old goats by intra-nasal and intravenous route of cell virus suspension and from infectious mashed tissue. The clinical signs were observed and goats were euthanized at predetermined clinical score level for post-mortem examinations and PPRV detection by RT-PCR. Clinical signs of infection were present, pyrexia, serous-mucopurulent nasal discharges, coughing, diarrhea and asthenia, for both cell virus suspension and infectious mashed tissue. PPRV genome was highly detected in swabs and tissues with clinical signs dominated by pulmonary attack and digestive symptoms secondary. RESULTS: Results of this study indicates that PPRV is an invasive infection in animals that in a short period, less than 10 days, invade all vital organs. On live animals, early diagnostic may be easily done on lacrimal and rectal swabs. CONCLUSION: The experimental PPRV-infection model using the cell virus suspension is suitable for vaccine evaluation as a standard model.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedades de las Cabras / Peste de los Pequeños Rumiantes Tipo de estudio: Etiology_studies / Prognostic_studies / Screening_studies Límite: Animals Idioma: En Revista: BMC Vet Res Asunto de la revista: MEDICINA VETERINARIA Año: 2019 Tipo del documento: Article País de afiliación: Marruecos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedades de las Cabras / Peste de los Pequeños Rumiantes Tipo de estudio: Etiology_studies / Prognostic_studies / Screening_studies Límite: Animals Idioma: En Revista: BMC Vet Res Asunto de la revista: MEDICINA VETERINARIA Año: 2019 Tipo del documento: Article País de afiliación: Marruecos