Autoimmune Hepatic Failure Following Acute Hepatitis A is Accompanied by Inflammatory Conversion of Regulatory T Cells.
Yonsei Med J
; 61(1): 100-102, 2020 Jan.
Article
en En
| MEDLINE
| ID: mdl-31887806
ABSTRACT
To evaluate the pathophysiology of autoimmune hepatitis (AIH) following acute hepatitis A (AHA) in immunologic aspects, we performed multi-color flow cytometry with peripheral blood mononuclear cells of a patient who underwent liver transplantation due to AIH-induced liver failure. Unlike general AHA patients, the proportion of tumor necrosis factor-α-producing Treg cells remained high for 6 months after diagnosis of AHA until she underwent a liver transplantation. The conversion of Treg cells into mediators of inflammation may have played a role in the autoimmune pathogenesis following AHA.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fallo Hepático
/
Linfocitos T Reguladores
/
Hepatitis Autoinmune
/
Hepatitis A
/
Inflamación
Límite:
Aged
/
Female
/
Humans
Idioma:
En
Revista:
Yonsei Med J
Año:
2020
Tipo del documento:
Article