Increased Activation of Default Mode Network in Early Parkinson's With Excessive Daytime Sleepiness.
Front Neurosci
; 13: 1334, 2019.
Article
en En
| MEDLINE
| ID: mdl-31920501
ABSTRACT
BACKGROUND AND OBJECTIVES:
The underlying neuropathology of excessive daytime sleepiness (EDS) remains elusive in Parkinson's disease (PD). We aim to investigate neural network changes that underlie EDS in PD.METHODS:
Early PD patients comprising eighty-one patients without EDS (EDS-) and seventeen patients with EDS (EDS+) received a resting state functional MRI scan and the Epworth Sleepiness Scale (ESS). Connectivities within the default mode network (DMN), motor and basal ganglia networks were compared between the EDS+ and EDS- groups. Correlations between network connectivity and the severity of EDS were investigated through linear regression.RESULTS:
EDS+ patients displayed a trend of increased network connectivity of the posterior DMN (pDMN). A significant positive correlation was found between connectivity of the ventromedial prefrontal cortex in the pDMN and ESS.CONCLUSION:
EDS+ patients are likely to display increased activation in the DMN, suggesting neural compensation in early PD or impaired attentiveness due to mechanisms such as mind-wandering.
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Bases de datos:
MEDLINE
Idioma:
En
Revista:
Front Neurosci
Año:
2019
Tipo del documento:
Article
País de afiliación:
Singapur