Nitric oxide synthase inhibitors negatively regulate respiration in isolated rodent cardiac and brain mitochondria.

Sakamuri, Siva S V P; Sperling, Jared A; Evans, Wesley R; Dholakia, Monica H; Albuck, Aaron L; Sure, Venkata N; Satou, Ryousuke; Mostany, Ricardo; Katakam, Prasad V G

Sakamuri, Siva S V P; Sperling, Jared A; Evans, Wesley R; Dholakia, Monica H; Albuck, Aaron L; Sure, Venkata N; Satou, Ryousuke; Mostany, Ricardo; Katakam, Prasad V G.

Afiliación

Sakamuri SSVP; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
Sperling JA; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
Evans WR; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
Dholakia MH; Tulane Brain Institute, Tulane University, New Orleans, Louisiana.
Albuck AL; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
Sure VN; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
Satou R; Tulane Brain Institute, Tulane University, New Orleans, Louisiana.
Mostany R; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
Katakam PVG; Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana.

Am J Physiol Heart Circ Physiol ; 318(2): H295-H300, 2020 02 01.

Article en En | MEDLINE | ID: mdl-31922888

Asunto(s)

Inhibidores Enzimáticos/farmacología; Mitocondrias Cardíacas/efectos de los fármacos; Mitocondrias Cardíacas/metabolismo; Mitocondrias/efectos de los fármacos; Mitocondrias/metabolismo; Óxido Nítrico Sintasa/antagonistas & inhibidores; Consumo de Oxígeno/efectos de los fármacos; Amidinas/farmacología; Animales; Encéfalo/efectos de los fármacos; Encéfalo/metabolismo; Ratones; Ratones Endogámicos C57BL; Óxido Nítrico Sintasa de Tipo I/antagonistas & inhibidores; Óxido Nítrico Sintasa de Tipo III/antagonistas & inhibidores; Ornitina/análogos & derivados; Ornitina/farmacología

Palabras clave

eNOS; mitochondrial nitric oxide synthase; mitochondrial respiration; nNOS; oxygen consumption rate

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Consumo de Oxígeno / Óxido Nítrico Sintasa / Inhibidores Enzimáticos / Mitocondrias / Mitocondrias Cardíacas Límite: Animals Idioma: En Revista: Am J Physiol Heart Circ Physiol Asunto de la revista: CARDIOLOGIA / FISIOLOGIA Año: 2020 Tipo del documento: Article

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