Simultaneous Quantitation of S(+)- and R(-)-Baclofen and Its Metabolite in Human Plasma and Cerebrospinal Fluid using LC-APCI-MS/MS: An Application for Clinical Studies.

He, Qingfeng; Chhonker, Yashpal S; McLaughlin, Matthew J; Murry, Daryl J

He, Qingfeng; Chhonker, Yashpal S; McLaughlin, Matthew J; Murry, Daryl J.

Afiliación

He Q; Clinical Pharmacology Laboratory, Department of Pharmacy Practice and Science, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Chhonker YS; Clinical Pharmacology Laboratory, Department of Pharmacy Practice and Science, University of Nebraska Medical Center, Omaha, NE 68198, USA.
McLaughlin MJ; Division of Rehabilitation Medicine, Children's Mercy Kansas City, UMKC School of Medicine, Kansas City, MO 64108, USA.
Murry DJ; Clinical Pharmacology Laboratory, Department of Pharmacy Practice and Science, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Molecules ; 25(2)2020 Jan 08.

Article en En | MEDLINE | ID: mdl-31936209

Asunto(s)

Presión Atmosférica; Baclofeno/sangre; Baclofeno/líquido cefalorraquídeo; Metaboloma; Espectrometría de Masas en Tándem; Baclofeno/química; Calibración; Cromatografía Liquida; Monitoreo de Drogas; Femenino; Humanos; Masculino; Estereoisomerismo; Adulto Joven

Palabras clave

3-(4-chlorophenyl)-4 hydroxybutyric acid (CHBA); CSF; LC-MS/MS; baclofen; chiral separation; pharmacokinetics; spasticity

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Presión Atmosférica / Baclofeno / Espectrometría de Masas en Tándem / Metaboloma Límite: Adult / Female / Humans / Male Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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