Gram-negative Microbiota Blooms in Premature Twins Discordant for Parenteral Nutrition-associated Cholestasis.
J Pediatr Gastroenterol Nutr
; 70(5): 640-644, 2020 05.
Article
en En
| MEDLINE
| ID: mdl-31939866
ABSTRACT
Parenteral nutrition-associated cholestasis (PNAC) causes serious morbidity in the neonatal intensive care unit. Infection with gut-associated bacteria is associated with cholestasis, but the role of intestinal microbiota in PNAC is poorly understood. We examined the composition of stool microbiota from premature twins discordant for PNAC as a strategy to reduce confounding from variables associated with both microbiota and cholestasis. Eighty-four serial stool samples were included from 4 twin sets discordant for PNAC. Random Forests was utilized to determine genera most discriminatory in classifying samples from infants with and without PNAC. In infants with PNAC, we detected a significant increase in the relative abundance of Klebsiella, Veillonella, Enterobacter, and Enterococcus (Pâ<â0.05). Bray-Curtis dissimilarities in infants with PNAC were significantly different (Pâ<â0.05) from infants without PNAC. Our findings warrant further exploration in larger cohorts and experimental models of PNAC to determine if a microbiota signature predicts PNAC, as a basis for future interventions to mitigate liver injury.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Colestasis
/
Microbiota
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
/
Infant
/
Newborn
Idioma:
En
Revista:
J Pediatr Gastroenterol Nutr
Año:
2020
Tipo del documento:
Article
País de afiliación:
Ciudad del Vaticano