Trajectories of pain and anxiety in a longitudinal cohort of adolescent twins.
Depress Anxiety
; 37(5): 475-484, 2020 05.
Article
en En
| MEDLINE
| ID: mdl-31944483
ABSTRACT
BACKGROUND:
Adolescence is critical to intercept chronic/persistent pain and decipher its association with anxiety. We ascertained adolescent pain trajectories, their demographic and clinical correlates, the longitudinal association with opiate prescriptions at age 19, and the etiology of the covariation between adolescent pain problems and anxiety symptoms.METHODS:
Longitudinal assessment of 6 common pain problems at age 12, 13, 14, 15, and 17 years; 7 common anxiety symptoms at age 12, 13, and 14 years; opiates' prescriptions at age 19, in the Quebec Newborn Twin Study birth cohort of 667 twin pairs born between 1995-1998.RESULTS:
Analyses yielded three trajectories of "none-to-minimal" (34.3%), "sporadic" (56.7%), and "frequent" (9.0%) pain problems between age 12-17. Anxiety (odds ratios [OR] ORage12 2.38; confidence interval [CI] 1.26-4.47; ORage13 3.96; CI 1.73-9.05; ORage14 5.45; CI 2.67-11.11), the female sex (OR 3.69; CI 2.20-6.21), and lower socioeconomic status (OR 0.87; CI 0.77-0.98) were associated with the "frequent" compared to the "none-to-minimal" pain trajectory. Only the "frequent" pain trajectory predicted opioid prescriptions at age 19 (OR 4.14; CI 1.16-14.55). A twin bivariate latent growth curve model and a cross-lagged model showed that genetic factors and non-shared environmental factors common to both phenotypes influence the longitudinal association between anxiety and adolescent pain problems.CONCLUSIONS:
The relatively common, adolescent "frequent pain" trajectory predicts early opioid prescriptions, and anxiety and adolescent pain share multiple etiological components. These data can inform diagnostic reasoning, clinical practice, and help reducing opioid prescriptions and abuse.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Ansiedad
/
Prescripciones de Medicamentos
/
Dolor Crónico
/
Analgésicos Opioides
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Female
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Humans
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Male
/
Newborn
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Depress Anxiety
Asunto de la revista:
PSIQUIATRIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Canadá