SnapShot: Splicing Alterations in Cancer.
Cell
; 180(1): 208-208.e1, 2020 01 09.
Article
en En
| MEDLINE
| ID: mdl-31951519
ABSTRACT
RNA splicing, the spliceosome-catalyzed process by which pre-messenger RNA (pre-mRNA) is processed to mature mRNA, is altered in a number of ways in cancer. Tumor-specific splicing alterations are created by mutations that disrupt splicing-regulatory elements within genes and impair splicing recognition or by altering the RNA-binding preferences of individual splicing factors. This SnapShot summarizes our current understanding of splicing-factor alterations in cancers. To view this SnapShot, open or download the PDF.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Empalme Alternativo
/
Sitios de Empalme de ARN
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Cell
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos