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PARP1 V762A polymorphism affects the prognosis of myelodysplastic syndromes.
Gotoh, Nanami; Minato, Yusuke; Saitoh, Takayuki; Takahashi, Noriyuki; Kasamatsu, Tetsuhiro; Souma, Kana; Oda, Tsukasa; Hoshino, Takumi; Sakura, Toru; Ishizaki, Takuma; Shimizu, Hiroaki; Takizawa, Makiko; Yokohama, Akihiko; Tsukamoto, Norifumi; Handa, Hiroshi; Murakami, Hirokazu.
Afiliación
  • Gotoh N; Graduate School of Health Sciences, Gunma University, Gunma, Japan.
  • Minato Y; Department of Virology and Preventive Medicine, Gunma University Graduate School of Medicine, Gunma, Japan.
  • Saitoh T; Department of Anatomy and Cell Biology, Hyogo College of Medicine, Hyogo, Japan.
  • Takahashi N; Graduate School of Health Sciences, Gunma University, Gunma, Japan.
  • Kasamatsu T; Graduate School of Health Sciences, Gunma University, Gunma, Japan.
  • Souma K; Graduate School of Health Sciences, Gunma University, Gunma, Japan.
  • Oda T; Graduate School of Health Sciences, Gunma University, Gunma, Japan.
  • Hoshino T; Laboratory of Molecular Genetics, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, Japan.
  • Sakura T; Leukemia Research Center, Saiseikai Maebashi Hospital, Gunma, Japan.
  • Ishizaki T; Leukemia Research Center, Saiseikai Maebashi Hospital, Gunma, Japan.
  • Shimizu H; Department of Hematology, Gunma University Graduate School of Medicine, Gunma, Japan.
  • Takizawa M; Department of Hematology, Gunma University Graduate School of Medicine, Gunma, Japan.
  • Yokohama A; Department of Hematology, Gunma University Graduate School of Medicine, Gunma, Japan.
  • Tsukamoto N; Division of Blood Transfusion Service, Gunma University Hospital, Gunma, Japan.
  • Handa H; Oncology Center, Gunma University Hospital, Gunma, Japan.
  • Murakami H; Department of Hematology, Gunma University Graduate School of Medicine, Gunma, Japan.
Eur J Haematol ; 104(6): 526-537, 2020 Jun.
Article en En | MEDLINE | ID: mdl-32003046
OBJECTIVE: Myelodysplastic syndromes (MDS), caused by various genetic mutations in hematopoietic stem cells, are associated with highly variable outcomes. Poly (ADP-ribose) polymerase-1 (PARP1) plays an important role in DNA damage repair and contributes to the progression of several types of cancer. Here, we investigated the impact of PARP1 V762A polymorphism on the susceptibility to and prognosis of MDS. METHODS: Samples collected from 105 MDS patients and 202 race-matched healthy controls were subjected to polymerase chain reaction-restriction fragment length polymorphism for genotyping. RESULTS: The allele and genotype frequencies of PARP1 V762A did not differ between MDS patients and the control group. However, MDS patients with the PARP1 V762A non-AA genotype, which is associated with high gene activity, had shorter overall survival rates (P = .01) than those with the AA genotype. Multivariate analysis of overall survival also revealed PARP1 V762A non-AA genotype as a poor prognostic factor (P = .02). When patients were analyzed according to treatment history, the PARP1 V762A non-AA genotype was only associated with poor survival in patients who had received treatment (P = .02). CONCLUSION: PARP1 V762A polymorphism may be an independent prognostic factor for MDS, and a predictive biomarker for MDS treatment.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Polimorfismo Genético / Síndromes Mielodisplásicos / Poli(ADP-Ribosa) Polimerasa-1 Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Haematol Asunto de la revista: HEMATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Polimorfismo Genético / Síndromes Mielodisplásicos / Poli(ADP-Ribosa) Polimerasa-1 Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Haematol Asunto de la revista: HEMATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Japón