Control of cell shape during epithelial morphogenesis: recent advances.
Curr Opin Genet Dev
; 63: 1-8, 2020 08.
Article
en En
| MEDLINE
| ID: mdl-32092616
ABSTRACT
Morphogenesis is an essential process by which a given tissue, organ or organism acquires its final shape. A select number of mechanisms are used in order to drive epithelial morphogenesis, including cell shape changes as well as cell death or cell division. A cell's shape results from the combination of intrinsic properties of the actomyosin and microtubule (MTs) cytoskeletons, and extrinsic properties due to physical interactions with the neighbouring environment. While we now have a good understanding of the genetic pathways and some of the signalling pathways controlling cell shape changes, the mechanical properties of cells and their role in morphogenesis remain largely unexplored. Recent improvements in microscopy techniques and the development of modelling and quantitative methods have enabled a better understanding of the bio-mechanical events controlling cell shape during morphogenesis. This review aims to highlight recent findings elegantly unravelling and quantifying the contribution of mechanical forces during morphogenesis.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Citoesqueleto de Actina
/
Forma de la Célula
/
Células Epiteliales
/
Morfogénesis
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Genet Dev
Asunto de la revista:
GENETICA
Año:
2020
Tipo del documento:
Article