Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes.
Trends Parasitol
; 36(4): 337-355, 2020 04.
Article
en En
| MEDLINE
| ID: mdl-32191849
ABSTRACT
Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast nucleoid containing mitochondrial DNAs of two kinds maxicircles encoding ribosomal RNAs (rRNAs) and proteins and minicircles bearing guide RNAs (gRNAs) for mRNA editing. All RNAs are produced by a phage-type RNA polymerase as 3' extended precursors, which undergo exonucleolytic trimming. Most pre-mRNAs proceed through 3' adenylation, uridine insertion/deletion editing, and 3' A/U-tailing. The rRNAs and gRNAs are 3' uridylated. Historically, RNA editing has attracted major research effort, and recently essential pre- and postediting processing events have been discovered. Here, we classify the key players that transform primary transcripts into mature molecules and regulate their function and turnover.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Trypanosoma brucei brucei
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ARN Protozoario
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Edición de ARN
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ARN Mitocondrial
Límite:
Animals
Idioma:
En
Revista:
Trends Parasitol
Asunto de la revista:
PARASITOLOGIA
Año:
2020
Tipo del documento:
Article