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Extending the use of tadalafil scaffold: Development of novel selective phosphodiesterase 5 inhibitors and histone deacetylase inhibitors.
ElHady, Ahmed K; Shih, Shou-Ping; Chen, Yu-Cheng; Liu, Yi-Chang; Ahmed, Nermin S; Keeton, Adam B; Piazza, Gary A; Engel, Matthias; Abadi, Ashraf H; Abdel-Halim, Mohammad.
Afiliación
  • ElHady AK; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.
  • Shih SP; Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung 804, Taiwan; Doctoral Degree Program in Marine Biotechnology, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan.
  • Chen YC; The Ph.D. Program for Cancer Biology and Drug Discovery, China Medical University and Academia Sinica, Taichung 40402, Taiwan.
  • Liu YC; Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan; Department of Internal Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • Ahmed NS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.
  • Keeton AB; Department of Oncologic Sciences and Pharmacology, Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36608, USA.
  • Piazza GA; Department of Oncologic Sciences and Pharmacology, Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36608, USA.
  • Engel M; Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2.3, D-66123 Saarbrücken, Germany.
  • Abadi AH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.
  • Abdel-Halim M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt. Electronic address: mohammad.abdel-halim@guc.edu.eg.
Bioorg Chem ; 98: 103742, 2020 05.
Article en En | MEDLINE | ID: mdl-32199305
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fosfodiesterasas de Nucleótidos Cíclicos Tipo 5 / Inhibidores de Histona Desacetilasas / Inhibidores de Fosfodiesterasa 5 / Tadalafilo / Desarrollo de Medicamentos / Histona Desacetilasas Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2020 Tipo del documento: Article País de afiliación: Egipto
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fosfodiesterasas de Nucleótidos Cíclicos Tipo 5 / Inhibidores de Histona Desacetilasas / Inhibidores de Fosfodiesterasa 5 / Tadalafilo / Desarrollo de Medicamentos / Histona Desacetilasas Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2020 Tipo del documento: Article País de afiliación: Egipto