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Current Understanding of the Mechanism of Water Oxidation in Photosystem II and Its Relation to XFEL Data.
Cox, Nicholas; Pantazis, Dimitrios A; Lubitz, Wolfgang.
Afiliación
  • Cox N; Research School of Chemistry, The Australian National University, Canberra ACT 2601, Australia; email: nick.cox@anu.edu.au.
  • Pantazis DA; Max-Planck-Institut für Kohlenforschung, 45470 Mülheim an der Ruhr, Germany; email: dimitrios.pantazis@kofo.mpg.de.
  • Lubitz W; Max-Planck-Institut für Chemische Energiekonversion, 45470 Mülheim an der Ruhr, Germany; email: wolfgang.lubitz@cec.mpg.de.
Annu Rev Biochem ; 89: 795-820, 2020 06 20.
Article en En | MEDLINE | ID: mdl-32208765
ABSTRACT
The investigation of water oxidation in photosynthesis has remained a central topic in biochemical research for the last few decades due to the importance of this catalytic process for technological applications. Significant progress has been made following the 2011 report of a high-resolution X-ray crystallographic structure resolving the site of catalysis, a protein-bound Mn4CaOx complex, which passes through ≥5 intermediate states in the water-splitting cycle. Spectroscopic techniques complemented by quantum chemical calculations aided in understanding the electronic structure of the cofactor in all (detectable) states of the enzymatic process. Together with isotope labeling, these techniques also revealed the binding of the two substrate water molecules to the cluster. These results are described in the context of recent progress using X-ray crystallography with free-electron lasers on these intermediates. The data are instrumental for developing a model for the biological water oxidation cycle.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Oxígeno / Agua / Coenzimas / Complejo de Proteína del Fotosistema II / Manganeso Idioma: En Revista: Annu Rev Biochem Año: 2020 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Oxígeno / Agua / Coenzimas / Complejo de Proteína del Fotosistema II / Manganeso Idioma: En Revista: Annu Rev Biochem Año: 2020 Tipo del documento: Article