New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I-Interacting Kinase (TNNi3K).

Asquith, Christopher R M; Laitinen, Tuomo; Wells, Carrow I; Tizzard, Graham J; Zuercher, William J

Asquith, Christopher R M; Laitinen, Tuomo; Wells, Carrow I; Tizzard, Graham J; Zuercher, William J.

Afiliación

Asquith CRM; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Laitinen T; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Wells CI; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Tizzard GJ; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Zuercher WJ; UK National Crystallography Service, School of Chemistry, University of Southampton, Highfield Campus, Southampton SO17 1BJ, UK.

Molecules ; 25(7)2020 Apr 07.

Article en En | MEDLINE | ID: mdl-32272798

Asunto(s)

Compuestos de Anilina/farmacología; Miocitos Cardíacos/efectos de los fármacos; Inhibidores de Proteínas Quinasas/farmacología; Proteínas Serina-Treonina Quinasas/antagonistas & inhibidores; Quinazolinas/farmacología; Humanos; Miocitos Cardíacos/metabolismo; Troponina I/metabolismo

Palabras clave

4-anilino-quinazolines; cardiac troponin Iinteracting kinase (TNNi3K); conformational flexibility; hinge binder; kinase inhibitor design

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Quinazolinas / Proteínas Serina-Treonina Quinasas / Miocitos Cardíacos / Inhibidores de Proteínas Quinasas / Compuestos de Anilina Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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