Synthetic Studies of Neoclerodane Diterpenes from <i>Salvia divinorum</i>: Design, Synthesis, and Evaluation of Analogues with Improved Potency and G-protein Activation Bias at the µ-Opioid Receptor.

Crowley, Rachel S; Riley, Andrew P; Alder, Amy F; Anderson, Richard J; Luo, Dan; Kaska, Sophia; Maynez, Pamela; Kivell, Bronwyn M; Prisinzano, Thomas E

Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Design, Synthesis, and Evaluation of Analogues with Improved Potency and G-protein Activation Bias at the µ-Opioid Receptor.

Crowley, Rachel S; Riley, Andrew P; Alder, Amy F; Anderson, Richard J; Luo, Dan; Kaska, Sophia; Maynez, Pamela; Kivell, Bronwyn M; Prisinzano, Thomas E.

Afiliación

Crowley RS; Department of Medicinal Chemistry, School of Pharmacy, University of Kansas, Lawrence, Kansas 66047, United States.
Riley AP; Department of Chemistry, University of Kansas, Lawrence, Kansas 66045, United States.
Alder AF; School of Biological Sciences, Centre for Biodiscovery, Victoria University of Wellington, Wellington 6140, New Zealand.
Anderson RJ; School of Biological Sciences, Centre for Biodiscovery, Victoria University of Wellington, Wellington 6140, New Zealand.
Luo D; Department of Medicinal Chemistry, School of Pharmacy, University of Kansas, Lawrence, Kansas 66047, United States.
Kaska S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.
Maynez P; Department of Medicinal Chemistry, School of Pharmacy, University of Kansas, Lawrence, Kansas 66047, United States.
Kivell BM; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.
Prisinzano TE; Department of Medicinal Chemistry, School of Pharmacy, University of Kansas, Lawrence, Kansas 66047, United States.

ACS Chem Neurosci ; 11(12): 1781-1790, 2020 06 17.

Article en En | MEDLINE | ID: mdl-32383854

Asunto(s)

Diterpenos de Tipo Clerodano; Diterpenos; Salvia; Diterpenos de Tipo Clerodano/farmacología; Proteínas de Unión al GTP/metabolismo; Receptores Opioides kappa/metabolismo; Receptores Opioides mu/metabolismo; Salvia/metabolismo; Relación Estructura-Actividad

Palabras clave

MOR agonist; Structure−activity relationship; antinociceptive activity; biased ligand; functional selectivity; salvinorin A

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Salvia / Diterpenos de Tipo Clerodano / Diterpenos Idioma: En Revista: ACS Chem Neurosci Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google