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Identification of new arylsulfide derivatives as anti-melanogenic agents in a zebrafish model.
Ahn, Se Hwan; Hwang, Kyu-Seok; Shin, Dae-Seop; Kim, Seong Soon; Yang, Jung Yoon; Lee, Byung Hoi; Bae, Eun Jung; Choi, Byeong Wook; Bae, Myung Ae; Ahn, Jin Hee.
Afiliación
  • Ahn SH; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
  • Hwang KS; Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
  • Shin DS; Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
  • Kim SS; Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
  • Yang JY; Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
  • Lee BH; Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
  • Bae EJ; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
  • Choi BW; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
  • Bae MA; Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea. Electronic address: mbae@krict.re.kr.
  • Ahn JH; Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea. Electronic address: jhahn@gist.ac.kr.
Bioorg Med Chem Lett ; 30(13): 127201, 2020 07 01.
Article en En | MEDLINE | ID: mdl-32386982
ABSTRACT
A series of aryl sulfide derivatives was synthesized and evaluated for their anti-melanogenic activities. Several compounds, including 3e, 3i and 3q exhibited good anti-melanogenic activities. Among the derivatives, compound 3i showed good inhibitory effects against melanin synthesis and showed no toxicity in reconstituted human eye and skin tissues.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sulfuros / Preparaciones para Aclaramiento de la Piel / Melaninas Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sulfuros / Preparaciones para Aclaramiento de la Piel / Melaninas Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article