The Anti-Diabetic Drug Metformin Rescues Aberrant Mitochondrial Activity and Restrains Oxidative Stress in a Female Mouse Model of Rett Syndrome.

Zuliani, Ilaria; Urbinati, Chiara; Valenti, Daniela; Quattrini, Maria Cristina; Medici, Vanessa; Cosentino, Livia; Pietraforte, Donatella; Di Domenico, Fabio; Perluigi, Marzia; Vacca, Rosa Anna; De Filippis, Bianca

Zuliani, Ilaria; Urbinati, Chiara; Valenti, Daniela; Quattrini, Maria Cristina; Medici, Vanessa; Cosentino, Livia; Pietraforte, Donatella; Di Domenico, Fabio; Perluigi, Marzia; Vacca, Rosa Anna; De Filippis, Bianca.

Afiliación

Zuliani I; Department of Biochemical Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Urbinati C; Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Valenti D; Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Council of Research, 70126 Bari, Italy.
Quattrini MC; Core Facilities, Istituto Superiore di Sanità, 00161 Rome, Italy.
Medici V; Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Cosentino L; Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Pietraforte D; Core Facilities, Istituto Superiore di Sanità, 00161 Rome, Italy.
Di Domenico F; Department of Biochemical Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Perluigi M; Department of Biochemical Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Vacca RA; Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Council of Research, 70126 Bari, Italy.
De Filippis B; Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, 00161 Rome, Italy.

J Clin Med ; 9(6)2020 Jun 01.

Article en En | MEDLINE | ID: mdl-32492904

Palabras clave

Nrf2; PGC-1α; Rett syndrome; metformin; repurposing

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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2020 Tipo del documento: Article País de afiliación: Italia