[Philadelphia chromosome-positive acute lymphoblastic leukemia complicated by bone marrow necrosis during consolidation chemotherapy].
Rinsho Ketsueki
; 61(5): 462-467, 2020.
Article
en Ja
| MEDLINE
| ID: mdl-32507809
ABSTRACT
A 46-year-old man who had previously undergone open surgery for renal cell carcinoma (RCC) developed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-ALL). After the induction therapy, he achieved complete molecular remission. However, fever and bilateral buttock pain continued during the consolidation therapy. 18F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) showed FDG accumulation in both iliac bones and in the sacrum; however, no causative diseases, including relapse of Ph-ALL and RCC, were detected. Iliac bone marrow biopsy revealed bone marrow necrosis (BMN), the etiology of which was presumed to be the leukemia itself and the therapeutic response to chemotherapy. Fever resolution and buttock pain alleviation were observed over the next months. We observed diffuse fibrosis in the bone marrow at day 162 and day 364 after cord blood transplantation. Moreover, the FDG accumulation was significantly reduced on PET-CT. BMN is not widely recognized despite its potential association with hematologic malignancies. Additional cases of BMN should be reviewed to clarify BMN etiology and clinical features.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Cromosoma Filadelfia
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Límite:
Humans
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Male
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Middle aged
Idioma:
Ja
Revista:
Rinsho Ketsueki
Año:
2020
Tipo del documento:
Article