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Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer's Disease.
Kupski, Oliver; Funk, Lisa-Marie; Sautner, Viktor; Seifert, Franziska; Worbs, Brigitte; Ramsbeck, Daniel; Meyer, Franc; Diederichsen, Ulf; Buchholz, Mirko; Schilling, Stephan; Demuth, Hans-Ulrich; Tittmann, Kai.
Afiliación
  • Kupski O; Department of Molecular Enzymology, Georg-August University Göttingen, Julia-Lermontowa-Weg 3, 37077 Göttingen, Germany.
  • Funk LM; Department of Structural Dynamics, Max-Planck-Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
  • Sautner V; Department of Molecular Enzymology, Georg-August University Göttingen, Julia-Lermontowa-Weg 3, 37077 Göttingen, Germany.
  • Seifert F; Department of Structural Dynamics, Max-Planck-Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
  • Worbs B; Department of Molecular Enzymology, Georg-August University Göttingen, Julia-Lermontowa-Weg 3, 37077 Göttingen, Germany.
  • Ramsbeck D; Department of Structural Dynamics, Max-Planck-Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
  • Meyer F; Department of Molecular Enzymology, Georg-August University Göttingen, Julia-Lermontowa-Weg 3, 37077 Göttingen, Germany.
  • Diederichsen U; Institute for Organic and Biomolecular Chemistry, Georg-August University Göttingen, Tammannstraß 2, 37077 Göttingen, Germany.
  • Buchholz M; Fraunhofer Institute for Cell Therapy und Immunology IZI, Department of Drug Design and Target Validation, Weinbergweg 22, 06120 Halle/Saale, Germany.
  • Schilling S; Institute for Inorganic Chemistry, Georg-August University Göttingen, Tammannstraße 4, 37077 Göttingen, Germany.
  • Demuth HU; Institute for Organic and Biomolecular Chemistry, Georg-August University Göttingen, Tammannstraß 2, 37077 Göttingen, Germany.
  • Tittmann K; Fraunhofer Institute for Cell Therapy und Immunology IZI, Department of Drug Design and Target Validation, Weinbergweg 22, 06120 Halle/Saale, Germany.
Biochemistry ; 59(28): 2585-2591, 2020 07 21.
Article en En | MEDLINE | ID: mdl-32551535
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Aminoaciltransferasas / Inhibidores Enzimáticos / Enfermedad de Alzheimer / Hidrazinas Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Biochemistry Año: 2020 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Aminoaciltransferasas / Inhibidores Enzimáticos / Enfermedad de Alzheimer / Hidrazinas Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Biochemistry Año: 2020 Tipo del documento: Article País de afiliación: Alemania