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Identification of dibucaine derivatives as novel potent enterovirus 2C helicase inhibitors: In vitro, in vivo, and combination therapy study.
Tang, Qi; Xu, Zhichao; Jin, Mengyu; Shu, Ting; Chen, Yinuo; Feng, Leilei; Zhang, Qiuhan; Lan, Ke; Wu, Shuwen; Zhou, Hai-Bing.
Afiliación
  • Tang Q; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
  • Xu Z; Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Frontier Science Center for Immunology and Metabolism, Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China.
  • Jin M; Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Frontier Science Center for Immunology and Metabolism, Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China.
  • Shu T; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, 430071, China.
  • Chen Y; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
  • Feng L; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
  • Zhang Q; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
  • Lan K; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China; Medical Research Institute, Wuhan University, Wuhan, 430071, China. Electronic address: klan@whu.edu.cn.
  • Wu S; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China. Electronic address: shuwenwu@hotmail.com.
  • Zhou HB; Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Frontier Science Center for Immunology and Metabolism, Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China. Electronic address: zhouhb@whu.edu.cn.
Eur J Med Chem ; 202: 112310, 2020 Sep 15.
Article en En | MEDLINE | ID: mdl-32619885
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Antivirales / Proteínas Virales / ARN Helicasas / Enterovirus Humano A / Dibucaína / Infecciones por Enterovirus / Inhibidores Enzimáticos Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2020 Tipo del documento: Article País de afiliación: China
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Antivirales / Proteínas Virales / ARN Helicasas / Enterovirus Humano A / Dibucaína / Infecciones por Enterovirus / Inhibidores Enzimáticos Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2020 Tipo del documento: Article País de afiliación: China