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Frequency-specific alteration of functional connectivity density in bipolar disorder depression.
Yang, Yang; Cui, Qian; Pang, Yajing; Chen, Yuyan; Tang, Qin; Guo, Xiaonan; Han, Shaoqiang; Ameen Fateh, Ahmed; Lu, Fengmei; He, Zongling; Huang, Jing; Xie, Ailing; Li, Di; Lei, Ting; Wang, Yifeng; Chen, Huafu.
Afiliación
  • Yang Y; The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
  • Cui Q; School of Public Affairs and Administration, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: qiancui26@gmail.com.
  • Pang Y; The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
  • Chen Y; The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
  • Tang Q; The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
  • Guo X; The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
  • Han S; The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
  • Ameen Fateh A; The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
  • Lu F; The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
  • He Z; The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
  • Huang J; The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
  • Xie A; School of Public Affairs and Administration, University of Electronic Science and Technology of China, Chengdu, China.
  • Li D; The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
  • Lei T; School of Public Affairs and Administration, University of Electronic Science and Technology of China, Chengdu, China.
  • Wang Y; The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
  • Chen H; The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China; MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China; High-Field Magnetic R
Prog Neuropsychopharmacol Biol Psychiatry ; 104: 110026, 2021 01 10.
Article en En | MEDLINE | ID: mdl-32621959
ABSTRACT
Functional dysconnectivity has been widely reported in bipolar disorder during depressive episodes (BDD). However, the frequency-specific alterations of functional connectivity (FC) in BDD remain poorly understood. To address this issue, the FC patterns across slow-5 (0.01-0.027 Hz) and slow-4 (0.027-0.073 Hz) bands were computed using resting-state functional magnetic resonance imaging data from 37 BDD patients and 56 healthy controls (HCs). Short-range (local) FC density (lfcd) and long-range FC density (lrfcd) were calculated, and two-way analysis of variance was performed to ascertain the main effect of diagnosis and interaction effects between diagnosis and frequency. The BDD patients showed increased lfcd in the midline cerebelum. Meanwhile, the BDD patients showed increased lrfcd in the left supplementary motor cortex and right striatum and decreased lrfcd in the bilateral inferior temporal gyrus and left angular gyrus (AG) compared with the HCs. A significant frequency-by-diagnosis interaction was observed. In the slow-4 band, the BDD patients showed increased lfcd in the left pre-/postcentral gyrus and left fusiform gyrus (FG) and increased lrfcd in the left lingual gyrus (LG). In the slow-5 band, the BDD patients showed decreased lrfcd in the left LG. Moreover, the increased lfcd in the left FG in the slow-4 band was correlated with clinical progression and decreased lrfcd in the left AG was correlated with depressive severity. These results suggest that the presence of aberrant communication in the default mode network, sensory network, and subcortical and limbic modulating regions (striatum and midline cerebelum), which may offer a new framework for the understanding of the pathophysiological mechanisms of BDD.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Trastorno Bipolar / Encéfalo / Red Nerviosa Límite: Adult / Female / Humans / Male Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Trastorno Bipolar / Encéfalo / Red Nerviosa Límite: Adult / Female / Humans / Male Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Año: 2021 Tipo del documento: Article País de afiliación: China