Human ileal organoid model recapitulates clinical incidence of diarrhea associated with small molecule drugs.

Belair, David G; Visconti, Richard J; Hong, Miyoun; Marella, Mathieu; Peters, Matthew F; Scott, Clay W; Kolaja, Kyle L

Belair, David G; Visconti, Richard J; Hong, Miyoun; Marella, Mathieu; Peters, Matthew F; Scott, Clay W; Kolaja, Kyle L.

Afiliación

Belair DG; Investigative Toxicology, Nonclinical Development, Celgene Corporation, Summit, NJ, USA.
Visconti RJ; Investigative Toxicology, Nonclinical Development, Celgene Corporation, Summit, NJ, USA.
Hong M; Investigative Toxicology, Nonclinical Development, Celgene Corporation, Summit, NJ, USA.
Marella M; Histology and Pathology, Nonclinical Development, Celgene Corporation, Summit, NJ, USA.
Peters MF; Oncology Safety, BioPharmaceuticals R&D, AstraZeneca, Boston, MA, USA.
Scott CW; Oncology Safety, BioPharmaceuticals R&D, AstraZeneca, Boston, MA, USA.
Kolaja KL; Investigative Toxicology, Nonclinical Development, Celgene Corporation, Summit, NJ, USA. Electronic address: kyle.kolaja@bms.com.

Toxicol In Vitro ; 68: 104928, 2020 Oct.

Article en En | MEDLINE | ID: mdl-32622998

Asunto(s)

Diarrea/inducido químicamente; Íleon; Modelos Biológicos; Organoides; Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos; Humanos; Preparaciones Farmacéuticas

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Organoides / Diarrea / Íleon / Modelos Biológicos Tipo de estudio: Incidence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Toxicol In Vitro Asunto de la revista: TOXICOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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