Establishment and validation of a novel droplet digital PCR assay for ultrasensitive detection and dynamic monitoring of EGFR mutations in peripheral blood samples of non-small-cell lung cancer patients.

Tang, Chuanhao; Zhu, Lingxiang; Zhang, Lijuan; Tan, Chianru; Peng, Zhiyong; Liu, Baoxia; Liu, Wenjing; Hu, Haixu; Bai, Yu; Wang, Bo; Lin, Li; Liang, Jun; Li, Xiaoyan; Guo, Yong; Liu, Yi

Tang, Chuanhao; Zhu, Lingxiang; Zhang, Lijuan; Tan, Chianru; Peng, Zhiyong; Liu, Baoxia; Liu, Wenjing; Hu, Haixu; Bai, Yu; Wang, Bo; Lin, Li; Liang, Jun; Li, Xiaoyan; Guo, Yong; Liu, Yi.

Afiliación

Tang C; Department of Medical Oncology, Peking University International Hospital, Beijing 102206, China; Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China.
Zhu L; National Research Institute for Family Planning, Beijing 100081, China.
Zhang L; Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China.
Tan C; Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China.
Peng Z; TargetingOne Corporation, Beijing 100190, China.
Liu B; TargetingOne Corporation, Beijing 100190, China.
Liu W; Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China.
Hu H; Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China.
Bai Y; TargetingOne Corporation, Beijing 100190, China.
Wang B; TargetingOne Corporation, Beijing 100190, China.
Lin L; Department of Medical Oncology, Peking University International Hospital, Beijing 102206, China.
Liang J; Department of Medical Oncology, Peking University International Hospital, Beijing 102206, China.
Li X; Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China; Department of Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China. Electronic address: lixiaoyan@bjtth.org.
Guo Y; Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China. Electronic address: yongguo@tsinghua.edu.cn.
Liu Y; Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China. Electronic address: liuyi790114@163.com.

Clin Chim Acta ; 510: 88-96, 2020 Nov.

Article en En | MEDLINE | ID: mdl-32645388

Asunto(s)

Carcinoma de Pulmón de Células no Pequeñas; Neoplasias Pulmonares; Carcinoma de Pulmón de Células no Pequeñas/diagnóstico; Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico; Carcinoma de Pulmón de Células no Pequeñas/genética; Resistencia a Antineoplásicos/genética; Receptores ErbB/genética; Humanos; Neoplasias Pulmonares/diagnóstico; Neoplasias Pulmonares/tratamiento farmacológico; Neoplasias Pulmonares/genética; Mutación; Reacción en Cadena de la Polimerasa; Inhibidores de Proteínas Quinasas/farmacología; Inhibidores de Proteínas Quinasas/uso terapéutico

Palabras clave

Amplification refractory mutation system (ARMS); Droplet digital PCR (ddPCR); Epidermal growth factor receptor (EGFR); Mutation abundance; Non-small-cell lung cancer (NSCLC); Tyrosine kinase inhibitor (TKI)

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Clin Chim Acta Año: 2020 Tipo del documento: Article País de afiliación: China

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