Generative modelling of the thalamo-cortical circuit mechanisms underlying the neurophysiological effects of ketamine.
Neuroimage
; 221: 117189, 2020 11 01.
Article
en En
| MEDLINE
| ID: mdl-32711064
ABSTRACT
Cortical recordings of task-induced oscillations following subanaesthetic ketamine administration demonstrate alterations in amplitude, including increases at high-frequencies (gamma) and reductions at low frequencies (theta, alpha). To investigate the population-level interactions underlying these changes, we implemented a thalamo-cortical model (TCM) capable of recapitulating broadband spectral responses. Compared with an existing cortex-only 4-population model, Bayesian Model Selection preferred the TCM. The model was able to accurately and significantly recapitulate ketamine-induced reductions in alpha amplitude and increases in gamma amplitude. Parameter analysis revealed no change in receptor time-constants but significant increases in select synaptic connectivity with ketamine. Significantly increased connections included both AMPA and NMDA mediated connections from layer 2/3 superficial pyramidal cells to inhibitory interneurons and both GABAA and NMDA mediated within-population gain control of layer 5 pyramidal cells. These results support the use of extended generative models for explaining oscillatory data and provide in silico support for ketamine's ability to alter local coupling mediated by NMDA, AMPA and GABA-A.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Tálamo
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Magnetoencefalografía
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Corteza Cerebral
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Células Piramidales
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Antagonistas de Aminoácidos Excitadores
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Ondas Encefálicas
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Interneuronas
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Ketamina
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Modelos Biológicos
Límite:
Adolescent
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Adult
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Neuroimage
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
2020
Tipo del documento:
Article