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Dysregulated metabolism of polyunsaturated fatty acids in eosinophilic allergic diseases.
Miyata, Jun; Fukunaga, Koichi; Kawashima, Yusuke; Ohara, Osamu; Kawana, Akihiko; Asano, Koichiro; Arita, Makoto.
Afiliación
  • Miyata J; Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan; Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan; Division of Pulmonary Medicine, Department of Medicine, Keio Unive
  • Fukunaga K; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan. Electronic address: k-fuku@jf7.so-net.ne.jp.
  • Kawashima Y; Department of Applied Genomics, Kazusa DNA Research Institute, Chiba, Japan; Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. Electronic address: ykawashi@kazusa.or.jp.
  • Ohara O; Department of Applied Genomics, Kazusa DNA Research Institute, Chiba, Japan; Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. Electronic address: ohara@kazusa.or.jp.
  • Kawana A; Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan. Electronic address: kawana59@ndmc.ac.jp.
  • Asano K; Division of Pulmonary Medicine, Department of Medicine, Tokai University, School of Medicine, Kanagawa, Japan. Electronic address: ko-asano@tokai-u.jp.
  • Arita M; Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan; Cellular and Molecular Epigenetics Laboratory, Graduate School of Medical Life Science, Yokohama City University, Kanagawa, Japan; Division of Physiological Chemistry and Metabolism, Graduate School of Pharm
Prostaglandins Other Lipid Mediat ; 150: 106477, 2020 10.
Article en En | MEDLINE | ID: mdl-32711128
ABSTRACT
Polyunsaturated fatty acids (PUFAs), represented by the omega-6 fatty acid arachidonic acid (AA) and omega-3 fatty acid docosahexaenoic acid (DHA), are essential components of the human body. PUFAs are converted enzymatically into bioactive lipid mediators, including AA-derived cysteinyl leukotrienes (cys-LTs) and lipoxins and DHA-derived protectins, which orchestrate a wide range of immunological responses. For instance, eosinophils possess the biosynthetic capacity of various lipid mediators through multiple enzymes, including 5-lipoxygenase and 15-lipoxygenase, and play central roles in the regulation of allergic diseases. Dysregulated metabolism of PUFAs is reported, especially in severe asthma, aspirin-exacerbated respiratory disease, and eosinophilic chronic rhinosinusitis (ECRS), which is characterized by the overproduction of cys-LTs and impaired synthesis of pro-resolving mediators. Recently, by performing a multi-omics analysis (lipidomics, proteomics, and transcriptomics), we demonstrated the metabolic derangement of eosinophils in inflamed tissues of patients with ECRS. This abnormality occurred subsequent to altered enzyme expression of gamma-glutamyl transferase-5. In this review, we summarize the previous findings of dysregulated PUFA metabolism in allergic diseases, and discuss future prospective therapeutic strategies for correcting this imbalance.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Asma / Eosinófilos / Ácidos Grasos Insaturados / Hipersensibilidad / Inflamación Límite: Animals / Humans Idioma: En Revista: Prostaglandins Other Lipid Mediat Asunto de la revista: ENDOCRINOLOGIA Año: 2020 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Asma / Eosinófilos / Ácidos Grasos Insaturados / Hipersensibilidad / Inflamación Límite: Animals / Humans Idioma: En Revista: Prostaglandins Other Lipid Mediat Asunto de la revista: ENDOCRINOLOGIA Año: 2020 Tipo del documento: Article