Tissue-Specific Decellularization Methods: Rationale and Strategies to Achieve Regenerative Compounds.
Int J Mol Sci
; 21(15)2020 Jul 30.
Article
en En
| MEDLINE
| ID: mdl-32751654
ABSTRACT
The extracellular matrix (ECM) is a complex network with multiple functions, including specific functions during tissue regeneration. Precisely, the properties of the ECM have been thoroughly used in tissue engineering and regenerative medicine research, aiming to restore the function of damaged or dysfunctional tissues. Tissue decellularization is gaining momentum as a technique to obtain potentially implantable decellularized extracellular matrix (dECM) with well-preserved key components. Interestingly, the tissue-specific dECM is becoming a feasible option to carry out regenerative medicine research, with multiple advantages compared to other approaches. This review provides an overview of the most common methods used to obtain the dECM and summarizes the strategies adopted to decellularize specific tissues, aiming to provide a helpful guide for future research development.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Ingeniería de Tejidos
/
Medicina Regenerativa
/
Matriz Extracelular
Límite:
Humans
Idioma:
En
Revista:
Int J Mol Sci
Año:
2020
Tipo del documento:
Article
País de afiliación:
España