Pachymic acid protects oocyte by improving the ovarian microenvironment in polycystic ovary syndrome mice.
Biol Reprod
; 103(5): 1085-1098, 2020 10 29.
Article
en En
| MEDLINE
| ID: mdl-32776126
ABSTRACT
Women with polycystic ovary syndrome (PCOS) are characterized by endocrine disorders accompanied by a decline in oocyte quality. In this study, we generated a PCOS mice model by hypodermic injection of dehydroepiandrosterone, and metformin was used as a positive control drug to study the effect of pachymic acid (PA) on endocrine and oocyte quality in PCOS mice. Compared with the model group, the mice treated with PA showed the following changes (slower weight gain, improved abnormal metabolism; increased development potential of GV oocytes, reduced number of abnormal MII oocytes, and damaged embryos; lower expression of ovarian-related genes in ovarian tissue and pro-inflammatory cytokines in adipose tissue). All these aspects show similar effects on metformin. Most notably, PA is superior to metformin in improving inflammation of adipose tissue and mitochondrial abnormalities. It is suggested that PA has the similar effect with metformin, which can improve the endocrine environment and oocyte quality of PCOS mice. These findings suggest that PA has the similar effect with metformin, which can improve the endocrine environment and oocyte quality of PCOS mice.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Oocitos
/
Ovario
/
Síndrome del Ovario Poliquístico
/
Triterpenos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Biol Reprod
Año:
2020
Tipo del documento:
Article
País de afiliación:
China