Progress in Neoantigen Targeted Cancer Immunotherapies.
Front Cell Dev Biol
; 8: 728, 2020.
Article
en En
| MEDLINE
| ID: mdl-32850843
ABSTRACT
Immunotherapies that harness the immune system to kill cancer cells have showed significant therapeutic efficacy in many human malignancies. A growing number of studies have highlighted the relevance of neoantigens in recognizing cancer cells by intrinsic T cells. Cancer neoantigens are a direct consequence of somatic mutations presenting on the surface of individual cancer cells. Neoantigens are fully cancer-specific and exempt from central tolerance. In addition, neoantigens are important targets for checkpoint blockade therapy. Recently, technological innovations have made neoantigen discovery possible in a variety of malignancies, thus providing an impetus to develop novel immunotherapies that selectively enhance T cell reactivity for the destruction of cancer cells while leaving normal tissues unharmed. In this review, we aim to introduce the methods of the identification of neoantigens, the mutational patterns of human cancers, related clinical trials, neoantigen burden and sensitivity to immune checkpoint blockade. Moreover, we focus on relevant challenges of targeting neoantigens for cancer treatment.
Texto completo:
1
Bases de datos:
MEDLINE
Idioma:
En
Revista:
Front Cell Dev Biol
Año:
2020
Tipo del documento:
Article
País de afiliación:
China