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De novo design of picomolar SARS-CoV-2 miniprotein inhibitors.
Cao, Longxing; Goreshnik, Inna; Coventry, Brian; Case, James Brett; Miller, Lauren; Kozodoy, Lisa; Chen, Rita E; Carter, Lauren; Walls, Alexandra C; Park, Young-Jun; Strauch, Eva-Maria; Stewart, Lance; Diamond, Michael S; Veesler, David; Baker, David.
Afiliación
  • Cao L; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Goreshnik I; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Coventry B; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Case JB; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Miller L; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Kozodoy L; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Chen RE; Molecular Engineering Graduate Program, University of Washington, Seattle, WA 98195, USA.
  • Carter L; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Walls AC; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Park YJ; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Strauch EM; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Stewart L; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Diamond MS; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Veesler D; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Baker D; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Science ; 370(6515): 426-431, 2020 10 23.
Article en En | MEDLINE | ID: mdl-32907861
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Antivirales / Diseño de Fármacos / Peptidil-Dipeptidasa A / Glicoproteína de la Espiga del Coronavirus / Betacoronavirus Límite: Animals Idioma: En Revista: Science Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Antivirales / Diseño de Fármacos / Peptidil-Dipeptidasa A / Glicoproteína de la Espiga del Coronavirus / Betacoronavirus Límite: Animals Idioma: En Revista: Science Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos