Integrative genomics and pathway analysis identified prevalent FA-BRCA pathway alterations in arsenic-associated urinary bladder carcinoma: Chronic arsenic accumulation in cancer tissues hampers the FA-BRCA pathway.

Basu, Mukta; Ghosh, Sabnam; Roychowdhury, Anirban; Samadder, Sudip; Das, Pijush; Addya, Sankar; Roy, Anup; Pal, Dilip Kumar; Roychoudhury, Susanta; Ghosh, Amlan; Panda, Chinmay Kumar

Basu, Mukta; Ghosh, Sabnam; Roychowdhury, Anirban; Samadder, Sudip; Das, Pijush; Addya, Sankar; Roy, Anup; Pal, Dilip Kumar; Roychoudhury, Susanta; Ghosh, Amlan; Panda, Chinmay Kumar.

Afiliación

Basu M; Department of Oncogene Regulation, Chittaranjan National Cancer Institute, 37 SPM Road, Kolkata 700026, India.
Ghosh S; Department of Life Science, Presidency University, 86/1, College Street, Kolkata 700073, India.
Roychowdhury A; Department of Oncogene Regulation, Chittaranjan National Cancer Institute, 37 SPM Road, Kolkata 700026, India.
Samadder S; Department of Oncogene Regulation, Chittaranjan National Cancer Institute, 37 SPM Road, Kolkata 700026, India.
Das P; Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata, West Bengal 700032, India.
Addya S; Department of Cancer Biology, Sidney Kimmel Cancer Centre, Thomas Jefferson University, Philadelphia, PA, USA.
Roy A; Nil Ratan Sarkar Medical College and Hospital, West Bengal, India.
Pal DK; Department of Urology, IPGMER, SSKM, 244 A.J.C. Bose Road, Kolkata 700020, India.
Roychoudhury S; Molecular Biology and Basic Research Division, Saroj Gupta Cancer Centre and Research Institute, Thakurpukur, Kolkata 700 063, India.
Ghosh A; Department of Life Science, Presidency University, 86/1, College Street, Kolkata 700073, India.
Panda CK; Department of Oncogene Regulation, Chittaranjan National Cancer Institute, 37 SPM Road, Kolkata 700026, India. Electronic address: chinmaykumar.panda@cnci.org.in.

Genomics ; 112(6): 5055-5065, 2020 11.

Article en En | MEDLINE | ID: mdl-32920123

Asunto(s)

Arsénico/toxicidad; Carcinoma/genética; Neoplasias de la Vejiga Urinaria/genética; Arsénico/metabolismo; Carcinoma/etiología; Carcinoma/metabolismo; Carcinoma/mortalidad; Aberraciones Cromosómicas; Variaciones en el Número de Copia de ADN; Reparación del ADN; Proteína del Grupo de Complementación D2 de la Anemia de Fanconi/genética; Proteínas del Grupo de Complementación de la Anemia de Fanconi/metabolismo; Perfilación de la Expresión Génica; Genes BRCA1; Genes BRCA2; Genómica; Redes y Vías Metabólicas; Repeticiones de Microsatélite; Transducción de Señal; Neoplasias de la Vejiga Urinaria/etiología; Neoplasias de la Vejiga Urinaria/metabolismo; Neoplasias de la Vejiga Urinaria/mortalidad

Palabras clave

Arsenic; FA-BRCA pathway; Ingenuity ® Pathway analysis; Microarray; RAD50; UIMC1

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Arsénico / Neoplasias de la Vejiga Urinaria / Carcinoma Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Genomics Asunto de la revista: GENETICA Año: 2020 Tipo del documento: Article País de afiliación: India

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