Gut Microbes' Impact on Oncogenic Drivers: Location Matters.

White, Michael G; Wargo, Jennifer A

White, Michael G; Wargo, Jennifer A.

Afiliación

White MG; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wargo JA; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: jwargo@mdanderson.org.

Mol Cell ; 79(6): 878-880, 2020 09 17.

Article en En | MEDLINE | ID: mdl-32946762

RESUMEN

Recent work by Kadosh et al. (2020) suggests that mutant p53 activity in gut epithelia is influenced by local production of microbial metabolites. The switch of p53 from tumor suppressor to oncogene is location-dependent and is impacted by microbially derived gallic acid.

Asunto(s)

Microbioma Gastrointestinal; Carcinogénesis; Humanos; Oncogenes; Proteína p53 Supresora de Tumor/genética

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Microbioma Gastrointestinal Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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