Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms.
Science
; 370(6519): 950-957, 2020 11 20.
Article
en En
| MEDLINE
| ID: mdl-32972994
ABSTRACT
Efficient therapeutic options are needed to control the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has caused more than 922,000 fatalities as of 13 September 2020. We report the isolation and characterization of two ultrapotent SARS-CoV-2 human neutralizing antibodies (S2E12 and S2M11) that protect hamsters against SARS-CoV-2 challenge. Cryo-electron microscopy structures show that S2E12 and S2M11 competitively block angiotensin-converting enzyme 2 (ACE2) attachment and that S2M11 also locks the spike in a closed conformation by recognition of a quaternary epitope spanning two adjacent receptor-binding domains. Antibody cocktails that include S2M11, S2E12, or the previously identified S309 antibody broadly neutralize a panel of circulating SARS-CoV-2 isolates and activate effector functions. Our results pave the way to implement antibody cocktails for prophylaxis or therapy, circumventing or limiting the emergence of viral escape mutants.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neumonía Viral
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Infecciones por Coronavirus
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Peptidil-Dipeptidasa A
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Anticuerpos Neutralizantes
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Pandemias
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Glicoproteína de la Espiga del Coronavirus
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Betacoronavirus
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Anticuerpos Antivirales
Límite:
Animals
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Humans
Idioma:
En
Revista:
Science
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos