A Crosstalk on Codon Usage in Genes Associated with Leukemia.
Biochem Genet
; 59(1): 235-255, 2021 Feb.
Article
en En
| MEDLINE
| ID: mdl-32989646
ABSTRACT
Leukemia is the outcome of aggregation of damaged white blood cells. Several genes were reported to be associated with the pathogenesis of leukemia. These genes were computationally analyzed to decipher their codon usage bias (CUB) and to identify the prime factors influencing the codon usage profile as no work was reported yet. The mean values of synonymous codon usage order (SCUO) parameter indicated low CUB of the genes. Significant positive association of SCUO with overall GC and positional GCs might signal the presence of mutational pressure. However, neutrality plot suggested the dominant role of natural selection across the genes. Along with natural selection, the role of mutation pressure was also prominent and that might be responsible for lower CUB (SCUO = 0.19) of genes. Low translational speed might permit accuracy in the process. A strong inverse relationship of translational rate was observed with CUB of genes and folding energy.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Codón
/
Análisis Mutacional de ADN
/
Leucemia
/
Predisposición Genética a la Enfermedad
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Genes Relacionados con las Neoplasias
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Biochem Genet
Año:
2021
Tipo del documento:
Article
País de afiliación:
India