Epitope-Specific Antibody Responses to a Plasmodium falciparum Subunit Vaccine Target in a Malaria-Endemic Population.
J Infect Dis
; 223(11): 1943-1947, 2021 06 04.
Article
en En
| MEDLINE
| ID: mdl-32992328
ABSTRACT
Circumsporozoite protein (CSP) coats the Plasmodium falciparum sporozoite surface and is a major malaria subunit vaccine target. We measured epitope-specific reactivity to field-derived CSP haplotypes in serum samples from Malian adults and children on a custom peptide microarray. Compared to children, adults showed greater antibody responses and responses to more variants in regions proximal to and within the central repeat region. Children acquired short-lived immunity to an epitope proximal to the central repeat region but not to the central repeat region itself. This approach has the potential to differentiate immunodominant from protective epitope-specific responses when combined with longitudinal infection data.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Anticuerpos Antiprotozoarios
/
Malaria Falciparum
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Vacunas contra la Malaria
/
Formación de Anticuerpos
Límite:
Adult
/
Child
/
Humans
País/Región como asunto:
Africa
Idioma:
En
Revista:
J Infect Dis
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos