A Multi-Center, Real-Life Experience on Liquid Biopsy Practice for EGFR Testing in Non-Small Cell Lung Cancer (NSCLC) Patients.
Diagnostics (Basel)
; 10(10)2020 09 28.
Article
en En
| MEDLINE
| ID: mdl-32998450
ABSTRACT
BACKGROUND:
circulating tumor DNA (ctDNA) is a source of tumor genetic material for EGFR testing in NSCLC. Real-word data about liquid biopsy (LB) clinical practice are lacking. The aim of the study was to describe the LB practice for EGFR detection in North Eastern Italy.METHODS:
we conducted a multi-regional survey on ctDNA testing practices in lung cancer patients.RESULTS:
Median time from blood collection to plasma separation was 50 min (20-120 min), median time from plasma extraction to ctDNA analysis was 24 h (30 min-5 days) and median turnaround time was 24 h (6 h-5 days). Four hundred and seventy five patients and 654 samples were tested. One hundred and ninety-two patients were tested at diagnosis, with 16% EGFR mutation rate. Among the 283 patients tested at disease progression, 35% were T790M+. Main differences in LB results between 2017 and 2018 were the number of LBs performed for each patient at disease progression (2.88 vs. 1.2, respectively) and the percentage of T790M+ patients (61% vs. 26%).
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Bases de datos:
MEDLINE
Idioma:
En
Revista:
Diagnostics (Basel)
Año:
2020
Tipo del documento:
Article
País de afiliación:
Italia