Prevalence of hepatitis B surface antigen and serological markers of other endemic infections in HIV-infected children, adolescents and pregnant women in Sierra Leone: A cross-sectional study.
Int J Infect Dis
; 102: 45-52, 2021 Jan.
Article
en En
| MEDLINE
| ID: mdl-33002619
ABSTRACT
OBJECTIVE:
To assess the prevalence of serological markers of HBV and endemic acute and chronic infections (HAV, HCV, CMV, HTLV-1/2 and syphilis) in HIV-infected children, adolescents and pregnant women in Sierra Leone.METHOD:
We conducted a cross-sectional study at the national children's and women's hospitals in Freetown. Logistic regression was used to assess predictors of HBsAg positivity.RESULTS:
183 HIV-infected participants were enrolled, comprising children (n = 88), adolescents (n = 47) and pregnant women (n = 48). All participants (100%) were CMV IgG-positive, while 56.8%, 93.6% and 100% of children, adolescents and pregnant women, respectively, were HAV IgG-positive. The prevalence of HCV, HTLV-1/2 and syphilis were <4%. HBV markers were distributed as follows-children HBsAg (2.3%), HBeAg (0%), anti-HBc (5.7%); adolescents HBsAg (17.0%), HBeAg (6.4%), anti-HBc (27.7%); and pregnant women HBsAg (18.8%), HBeAg (4.2%), anti-HBc (77.1%). Age >10 years, i.e., being born pre-2009 before implementation of routine hepatitis B immunization (aOR 5.05 [1.18-21.28]; p = 0.029) and CD4 count <350 cells/mm3 (aOR 3.97 [1.07-14.71]; p = 0.039) predicted HBsAg positivity.CONCLUSION:
A high burden of chronic HBV and other endemic infections was observed among HIV-infected patients born pre-2009 before implementation of routine HBV immunization in Sierra Leone, warranting targeted screening and immunization of this high-risk population.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Sífilis
/
Infecciones por VIH
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Hepatitis B
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Anticuerpos contra la Hepatitis B
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Antígenos e de la Hepatitis B
/
Antígenos de Superficie de la Hepatitis B
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
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Adult
/
Child
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Child, preschool
/
Female
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Humans
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Male
/
Pregnancy
País/Región como asunto:
Africa
Idioma:
En
Revista:
Int J Infect Dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
Año:
2021
Tipo del documento:
Article