Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular Remodeling in Pulmonary Arterial Hypertension.

Vitry, Géraldine; Paulin, Roxane; Grobs, Yann; Lampron, Marie-Claude; Shimauchi, Tsukasa; Lemay, Sarah-Eve; Tremblay, Eve; Habbout, Karima; Awada, Charifa; Bourgeois, Alice; Nadeau, Valérie; Paradis, Renée; Breuils-Bonnet, Sandra; Roux-Dalvai, Florence; Orcholski, Mark; Potus, François; Provencher, Steeve; Boucherat, Olivier; Bonnet, Sébastien

Vitry, Géraldine; Paulin, Roxane; Grobs, Yann; Lampron, Marie-Claude; Shimauchi, Tsukasa; Lemay, Sarah-Eve; Tremblay, Eve; Habbout, Karima; Awada, Charifa; Bourgeois, Alice; Nadeau, Valérie; Paradis, Renée; Breuils-Bonnet, Sandra; Roux-Dalvai, Florence; Orcholski, Mark; Potus, François; Provencher, Steeve; Boucherat, Olivier; Bonnet, Sébastien.

Afiliación

Vitry G; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Paulin R; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Grobs Y; Department of Medicine and.
Lampron MC; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Shimauchi T; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Lemay SE; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Tremblay E; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Habbout K; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Awada C; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Bourgeois A; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Nadeau V; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Paradis R; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Breuils-Bonnet S; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Roux-Dalvai F; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Orcholski M; Proteomics Platform, Laval University, Québec City, Quebec, Canada.
Potus F; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Provencher S; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Boucherat O; Pulmonary Hypertension Research Group, Quebec Heart and Lung Institute Research Centre, Québec City, Quebec, Canada; and.
Bonnet S; Department of Medicine and.

Am J Respir Crit Care Med ; 203(5): 614-627, 2021 03 01.

Article en En | MEDLINE | ID: mdl-33021405

Asunto(s)

Enzimas Reparadoras del ADN/genética; ADN/metabolismo; Estrés Oxidativo/genética; Monoéster Fosfórico Hidrolasas/genética; Hipertensión Arterial Pulmonar/genética; Arteria Pulmonar/metabolismo; Remodelación Vascular/genética; 8-Hidroxi-2'-Desoxicoguanosina/metabolismo; Adulto; Anciano; Animales; Apoptosis/genética; Western Blotting; Estudios de Casos y Controles; Proliferación Celular/genética; Cromatografía Liquida; Ensayo Cometa; Enzimas Reparadoras del ADN/antagonistas & inhibidores; Enzimas Reparadoras del ADN/metabolismo; Modelos Animales de Enfermedad; Femenino; Proteína Forkhead Box M1/metabolismo; Humanos; Técnicas In Vitro; Masculino; Persona de Mediana Edad; Músculo Liso Vascular/citología; Músculo Liso Vascular/metabolismo; Miocitos del Músculo Liso/metabolismo; Oxidación-Reducción; Monoéster Fosfórico Hidrolasas/antagonistas & inhibidores; Monoéster Fosfórico Hidrolasas/metabolismo; Hipertensión Arterial Pulmonar/metabolismo; Pirofosfatasas/antagonistas & inhibidores; Pirofosfatasas/genética; Pirofosfatasas/metabolismo; ARN Mensajero/metabolismo; Ratas; Espectrometría de Masas en Tándem; Regulación hacia Arriba

Palabras clave

DNA damage; MTH1; oxidative stress; pulmonary hypertension; smooth muscle cells

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Arteria Pulmonar / ADN / Monoéster Fosfórico Hidrolasas / Estrés Oxidativo / Enzimas Reparadoras del ADN / Remodelación Vascular / Hipertensión Arterial Pulmonar Tipo de estudio: Observational_studies Idioma: En Revista: Am J Respir Crit Care Med Asunto de la revista: TERAPIA INTENSIVA Año: 2021 Tipo del documento: Article

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