Trastuzumab-induced upregulation of a protein set in extracellular vesicles emitted by ErbB2-positive breast cancer cells correlates with their trastuzumab sensitivity.

Drucker, Arik; Yoo, Byong Hoon; Khan, Iman Aftab; Choi, Dongsic; Montermini, Laura; Liu, Xiaoyang; Jovanovic, Sanja; Younis, Tallal; Rosen, Kirill V

Drucker, Arik; Yoo, Byong Hoon; Khan, Iman Aftab; Choi, Dongsic; Montermini, Laura; Liu, Xiaoyang; Jovanovic, Sanja; Younis, Tallal; Rosen, Kirill V.

Afiliación

Drucker A; Department of Medicine, Dalhousie University, Halifax, NS, Canada.
Yoo BH; Departments of Pediatrics & Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada.
Khan IA; Departments of Pediatrics & Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada.
Choi D; Research Institute of the McGill University Health Centre, Glen Site, McGill University, Montreal, QC, Canada.
Montermini L; Research Institute of the McGill University Health Centre, Glen Site, McGill University, Montreal, QC, Canada.
Liu X; Departments of Pediatrics & Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada.
Jovanovic S; Department of Medicine, Dalhousie University, Halifax, NS, Canada.
Younis T; Department of Medicine, Dalhousie University, Halifax, NS, Canada.
Rosen KV; Departments of Pediatrics & Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada. kirill.rosen@dal.ca.

Breast Cancer Res ; 22(1): 105, 2020 10 06.

Article en En | MEDLINE | ID: mdl-33023655

Asunto(s)

Biomarcadores Farmacológicos/metabolismo; Neoplasias de la Mama/tratamiento farmacológico; Vesículas Extracelulares/metabolismo; Proteínas de la Membrana/metabolismo; Receptor ErbB-2/metabolismo; Trastuzumab/uso terapéutico; Adulto; Antineoplásicos Inmunológicos/uso terapéutico; Neoplasias de la Mama/metabolismo; Neoplasias de la Mama/patología; Línea Celular Tumoral; Cromograninas/metabolismo; Estudios de Cohortes; Femenino; Subunidades alfa de la Proteína de Unión al GTP G12-G13/metabolismo; Subunidades alfa de la Proteína de Unión al GTP Gs/metabolismo; Genes Supresores de Tumor; Humanos; Persona de Mediana Edad; Metástasis de la Neoplasia; Proteómica/métodos; Receptor ErbB-2/antagonistas & inhibidores; Regulación hacia Arriba; Proteínas de Unión al GTP rab/metabolismo

Palabras clave

Biomarkers; Breast cancer; ErbB2; Extracellular vesicles; HER2; Trastuzumab

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Receptor ErbB-2 / Biomarcadores Farmacológicos / Vesículas Extracelulares / Trastuzumab / Proteínas de la Membrana Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Breast Cancer Res Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Canadá

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