Astrocytes Protect Human Dopaminergic Neurons from &#945;-Synuclein Accumulation and Propagation.

Tsunemi, Taiji; Ishiguro, Yuta; Yoroisaka, Asako; Valdez, Clarissa; Miyamoto, Kengo; Ishikawa, Keiichi; Saiki, Shinji; Akamatsu, Wado; Hattori, Nobutaka; Krainc, Dimitri

Astrocytes Protect Human Dopaminergic Neurons from α-Synuclein Accumulation and Propagation.

Tsunemi, Taiji; Ishiguro, Yuta; Yoroisaka, Asako; Valdez, Clarissa; Miyamoto, Kengo; Ishikawa, Keiichi; Saiki, Shinji; Akamatsu, Wado; Hattori, Nobutaka; Krainc, Dimitri.

Afiliación

Tsunemi T; Ken & Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 dkrainc@nm.org t-tsunemi@juntendo.ac.jp.
Ishiguro Y; Department of Neurology, School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Yoroisaka A; Department of Neurology, School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Valdez C; Department of Neurology, School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Miyamoto K; Center for Genomic and Regenerative Medicine, School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Ishikawa K; Department of Neurology, School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Saiki S; Center for Genomic and Regenerative Medicine, School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Akamatsu W; Department of Neurology, School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Hattori N; Center for Genomic and Regenerative Medicine, School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Krainc D; Department of Neurology, School of Medicine, Juntendo University, Tokyo 113-8421, Japan.

J Neurosci ; 40(45): 8618-8628, 2020 11 04.

Article en En | MEDLINE | ID: mdl-33046546

Asunto(s)

Astrocitos/fisiología; Neuronas Dopaminérgicas/fisiología; alfa-Sinucleína/metabolismo; Adulto; Técnicas de Cocultivo; Neuronas Dopaminérgicas/metabolismo; Exosomas/metabolismo; Femenino; Humanos; Células Madre Pluripotentes Inducidas; Lisosomas/enzimología; Lisosomas/metabolismo; Masculino; Neuroglía/metabolismo; Trastornos Parkinsonianos/genética; Trastornos Parkinsonianos/metabolismo; ATPasas de Translocación de Protón/deficiencia; ATPasas de Translocación de Protón/genética; ATPasas de Translocación de Protón/metabolismo; Sinucleinopatías/genética; Sinucleinopatías/metabolismo; alfa-Sinucleína/biosíntesis

Palabras clave

KuforRakeb syndrome; Parkinson's disease; astrocyte; α-synuclein

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Astrocitos / Alfa-Sinucleína / Neuronas Dopaminérgicas Límite: Adult / Female / Humans / Male Idioma: En Revista: J Neurosci Año: 2020 Tipo del documento: Article

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