Metabolic plasticity of IDH1<i>-mutant</i> glioma cell lines is responsible for low sensitivity to glutaminase inhibition.

Ruiz-Rodado, Victor; Lita, Adrian; Dowdy, Tyrone; Celiku, Orieta; Saldana, Alejandra Cavazos; Wang, Herui; Yang, Chun Zhang; Chari, Raj; Li, Aiguo; Zhang, Wei; Song, Hua; Zhang, Meili; Ahn, Susie; Davis, Dionne; Chen, Xiang; Zhuang, Zhengping; Herold-Mende, Christel; Walters, Kylie J; Gilbert, Mark R; Larion, Mioara

Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition.

Ruiz-Rodado, Victor; Lita, Adrian; Dowdy, Tyrone; Celiku, Orieta; Saldana, Alejandra Cavazos; Wang, Herui; Yang, Chun Zhang; Chari, Raj; Li, Aiguo; Zhang, Wei; Song, Hua; Zhang, Meili; Ahn, Susie; Davis, Dionne; Chen, Xiang; Zhuang, Zhengping; Herold-Mende, Christel; Walters, Kylie J; Gilbert, Mark R; Larion, Mioara.

Afiliación

Ruiz-Rodado V; Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Building 37, Room 1136A, Bethesda, Maryland USA.
Lita A; Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Building 37, Room 1136A, Bethesda, Maryland USA.
Dowdy T; Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Building 37, Room 1136A, Bethesda, Maryland USA.
Celiku O; Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Building 37, Room 1136A, Bethesda, Maryland USA.
Saldana AC; Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Building 37, Room 1136A, Bethesda, Maryland USA.
Wang H; Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Building 37, Room 1136A, Bethesda, Maryland USA.
Yang CZ; Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Building 37, Room 1136A, Bethesda, Maryland USA.
Chari R; Genome Modification Core, Laboratory Animal Sciences Program, Frederick National Lab for Cancer Research, National Institutes of Health, Frederick, Maryland USA.
Li A; Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Building 37, Room 1136A, Bethesda, Maryland USA.
Zhang W; Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Building 37, Room 1136A, Bethesda, Maryland USA.
Song H; Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Building 37, Room 1136A, Bethesda, Maryland USA.
Zhang M; Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Building 37, Room 1136A, Bethesda, Maryland USA.
Ahn S; Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Building 37, Room 1136A, Bethesda, Maryland USA.
Davis D; Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Building 37, Room 1136A, Bethesda, Maryland USA.
Chen X; Structural Biophysics Laboratory, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Frederick, Maryland USA.
Zhuang Z; Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Building 37, Room 1136A, Bethesda, Maryland USA.
Herold-Mende C; Division of Neurosurgical Research, Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
Walters KJ; Structural Biophysics Laboratory, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Frederick, Maryland USA.
Gilbert MR; Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Building 37, Room 1136A, Bethesda, Maryland USA.
Larion M; Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 37 Convent Drive, Building 37, Room 1136A, Bethesda, Maryland USA.

Cancer Metab ; 8: 23, 2020.

Article en En | MEDLINE | ID: mdl-33101674

Palabras clave

13C tracing; AGI5198; CB839; Gliomas; Glutaminase; IDH1-mutant

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Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Diagnostic_studies Idioma: En Revista: Cancer Metab Año: 2020 Tipo del documento: Article