Association Between Serological Responses to Two Zoonotic Ruminant Pathogens and Esophageal Squamous Cell Carcinoma.
Vector Borne Zoonotic Dis
; 21(2): 125-127, 2021 02.
Article
en En
| MEDLINE
| ID: mdl-33121389
ABSTRACT
Questionnaire data have linked contact with ruminants to the risk of esophageal squamous cell carcinoma (ESCC) in high-risk Asian populations. To better understand this observed association, we investigated exposure to two major zoonotic ruminant pathogens relative to ESCC risk. Using enzyme-linked immunosorbent assay, immunofluorescence assay, and Brucella microagglutination test assays, we measured immunoglobulin G anti-Coxiella burnetii and anti-Brucella spp. antibodies in patients with ESCC (n = 177) and population-based controls (n = 177) matched by age, gender, and residence area from the Golestan case-control study in Iran. We found a similarly high seroprevalence of C. burnetii in ESCC cases and controls (75% and 80%, respectively), and a similarly low seroprevalence of Brucella spp. (0% and 0.6%, respectively). While documenting a high exposure to one of two zoonotic ruminant infections, this exposure failed to explain the observed association of ruminant contact and ESCC risk in this high-risk population.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fiebre Q
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Brucelosis
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Neoplasias Esofágicas
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Coxiella burnetii
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Carcinoma de Células Escamosas de Esófago
Tipo de estudio:
Observational_studies
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Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Vector Borne Zoonotic Dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
/
EPIDEMIOLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos