Primary Immunoglobulin G4-Related Laryngeal Disease: A Case Series and Review of Literature.
Clin Med Insights Case Rep
; 13: 1179547620960197, 2020.
Article
en En
| MEDLINE
| ID: mdl-33192112
ABSTRACT
OBJECTIVE:
Immunoglobulin G4-related disease (IgG4-RD) is an increasingly recognised cause of various systemic fibro-inflammatory conditions. However, laryngeal involvement as a primary feature is extremely rare. We aimed to report on a case series of such patients and examine the global literature relating to laryngeal involvement.METHODS:
Having previously reported a case of IgG4-RD laryngeal pseudotumour, we describe a case series of further 4 patients with primary laryngeal IgG4-RD managed by our UK quaternary airway service and provide a brief overview of laryngeal IgG4-RD.RESULTS:
Including our cases, 14 cases of primary laryngeal IgG4-RD have been reported. Vocal cord involvement is relatively uncommon. Repeat biopsies may be required to achieve histological diagnosis. Remission is achievable by commencement of immunomodulatory treatment, following which laryngeal reconstruction may be necessary.CONCLUSION:
Laryngeal involvement is a rare presentation of IgG4-RD, itself a rare and difficult-to-diagnose condition. A high and prolonged index of suspicion is necessary from both surgical and pathological specialists for correct diagnosis and management.
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Bases de datos:
MEDLINE
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En
Revista:
Clin Med Insights Case Rep
Año:
2020
Tipo del documento:
Article
País de afiliación:
Reino Unido