Lack of adipocyte purinergic P2Y<sub>6</sub> receptor greatly improves whole body glucose homeostasis.

Jain, Shanu; Pydi, Sai P; Toti, Kiran S; Robaye, Bernard; Idzko, Marco; Gavrilova, Oksana; Wess, Jürgen; Jacobson, Kenneth A

Lack of adipocyte purinergic P2Y₆ receptor greatly improves whole body glucose homeostasis.

Jain, Shanu; Pydi, Sai P; Toti, Kiran S; Robaye, Bernard; Idzko, Marco; Gavrilova, Oksana; Wess, Jürgen; Jacobson, Kenneth A.

Afiliación

Jain S; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.
Pydi SP; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.
Toti KS; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.
Robaye B; Institute of Interdisciplinary Research (IRIBHM), Université Libre de Bruxelles, 6041 Gosselies, Belgium.
Idzko M; Universitätsklinik für Innere Medizin II, Klinische Abteilung für Pulmologie, Medizinische Universität, 1090 Vienna, Austria.
Gavrilova O; Department of Pneumology, University Hospital Freiburg, 79106 Freiburg, Germany.
Wess J; Mouse Metabolism Core, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.
Jacobson KA; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.

Proc Natl Acad Sci U S A ; 117(48): 30763-30774, 2020 12 01.

Article en En | MEDLINE | ID: mdl-33199639

Asunto(s)

Adipocitos/metabolismo; Glucosa/metabolismo; Homeostasis; Receptores Purinérgicos P2/metabolismo; Adipocitos/efectos de los fármacos; Tejido Adiposo/metabolismo; Animales; Biomarcadores; Diabetes Mellitus Tipo 2/genética; Diabetes Mellitus Tipo 2/metabolismo; Dieta Alta en Grasa; Modelos Animales de Enfermedad; Metabolismo Energético; Regulación de la Expresión Génica/efectos de los fármacos; Inflamación/etiología; Inflamación/metabolismo; Proteínas Quinasas JNK Activadas por Mitógenos/metabolismo; Ratones; Ratones Noqueados; Mitocondrias/genética; Mitocondrias/metabolismo; Músculo Esquelético/metabolismo; Obesidad/etiología; Obesidad/metabolismo; Receptores Purinérgicos P2/genética

Palabras clave

GPCR; adipocyte; metabolism; nucleotides; obesity

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptores Purinérgicos P2 / Adipocitos / Glucosa / Homeostasis Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article

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