Tumor extracellular vesicles loaded with exogenous Let-7i and miR-142 can modulate both immune response and tumor microenvironment to initiate a powerful anti-tumor response.

Khani, Adeleh Taghi; Sharifzad, Farzaneh; Mardpour, Soura; Hassan, Zuhair Mohammad; Ebrahimi, Marzieh

Khani, Adeleh Taghi; Sharifzad, Farzaneh; Mardpour, Soura; Hassan, Zuhair Mohammad; Ebrahimi, Marzieh.

Afiliación

Khani AT; Tarbiat Modares University, Department of Immunology, Tehran, Iran; Department of Stem Cells and Developmental Biology, Cell Sciences Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. Electronic address: adeleh.taghikhani@modares.ac.ir.
Sharifzad F; Department of Stem Cells and Developmental Biology, Cell Sciences Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran; Department of Applied Cell Sciences, Kashan University of Medical Sciences, Kashan, Iran.
Mardpour S; Department of Stem Cells and Developmental Biology, Cell Sciences Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran; Tissue Engineering and Applied Cell Sciences Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, T
Hassan ZM; Tarbiat Modares University, Department of Immunology, Tehran, Iran. Electronic address: hasan_zm@modares.ac.ir.
Ebrahimi M; Department of Stem Cells and Developmental Biology, Cell Sciences Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. Electronic address: mebrahimi@royaninstitute.org.

Cancer Lett ; 501: 200-209, 2021 03 31.

Article en En | MEDLINE | ID: mdl-33220334

Asunto(s)

Vesículas Extracelulares/trasplante; Neoplasias Mamarias Experimentales/terapia; MicroARNs/genética; Animales; Antígenos de Neoplasias/genética; Células Dendríticas/metabolismo; Vesículas Extracelulares/genética; Femenino; Granzimas/metabolismo; Inyecciones Intramusculares; Interferón gamma/metabolismo; Activación de Linfocitos; Neoplasias Mamarias Experimentales/genética; Neoplasias Mamarias Experimentales/inmunología; Ratones; Linfocitos T/inmunología; Microambiente Tumoral

Palabras clave

Dendritic cell maturation and T cell activation; Tumor-derived extracellular vesicles; miRNA

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: MicroARNs / Vesículas Extracelulares / Neoplasias Mamarias Experimentales Límite: Animals Idioma: En Revista: Cancer Lett Año: 2021 Tipo del documento: Article

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