Effects of water restriction on social behavior and 5-HT neurons density in the dorsal and median raphe nuclei in mice.
Behav Brain Res
; 399: 113022, 2021 02 05.
Article
en En
| MEDLINE
| ID: mdl-33232678
ABSTRACT
We explored here the hypothesis that temporary chronic water restriction in mice affects social behavior, via its action on the density of 5-HT neurons in dorsal and median raphe nuclei (DRN and MRN). For that, we submitted adult C57BL/6 J mice to mild and controlled temporary dehydration, i.e., 6 h of water access every 48 h for 15 days. We investigated their social behavior in a social interaction task known to allow free and reciprocal social contact. Results showed that temporary dehydration increases significantly time spent in social contact and social dominance. It also expands 5-HT neuron density within both DRN and MRN and the behavioral and neuronal plasticity were positively correlated. Our findings suggest that disturbance in 5-HT neurotransmission caused by temporary dehydration stress unbalances choice processes of animals in social context.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Conducta Social
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Conducta Animal
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Núcleos del Rafe
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Serotonina
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Deshidratación
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Neuronas Serotoninérgicas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Behav Brain Res
Año:
2021
Tipo del documento:
Article