Pan-RAF Inhibition Shows Anti-Leukemic Activity in <i>RAS</i>-Mutant Acute Myeloid Leukemia Cells and Potentiates the Effect of Sorafenib in Cells with <i>FLT3</i> Mutation.

Khoury, Joseph D; Tashakori, Mehrnoosh; Yang, Hong; Loghavi, Sanam; Wang, Ying; Wang, Jing; Piya, Sujan; Borthakur, Gautam

Pan-RAF Inhibition Shows Anti-Leukemic Activity in RAS-Mutant Acute Myeloid Leukemia Cells and Potentiates the Effect of Sorafenib in Cells with FLT3 Mutation.

Khoury, Joseph D; Tashakori, Mehrnoosh; Yang, Hong; Loghavi, Sanam; Wang, Ying; Wang, Jing; Piya, Sujan; Borthakur, Gautam.

Afiliación

Khoury JD; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, MS-072, Houston, TX 77030, USA.
Tashakori M; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, MS-072, Houston, TX 77030, USA.
Yang H; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, MS-072, Houston, TX 77030, USA.
Loghavi S; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, MS-072, Houston, TX 77030, USA.
Wang Y; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Wang J; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Piya S; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, MS-072, Houston, TX 77030, USA.
Borthakur G; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, MS-072, Houston, TX 77030, USA.

Cancers (Basel) ; 12(12)2020 Nov 25.

Article en En | MEDLINE | ID: mdl-33255818

Palabras clave

FLT3; RAF; RAS; acute myeloid leukemia; preclinical

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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos