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Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients.
Picard, Marion; Yonekura, Satoru; Slowicka, Karolina; Petta, Ioanna; Rauber, Conrad; Routy, Bertrand; Richard, Corentin; Iebba, Valerio; Tidjani Alou, Maryam; Becharef, Sonia; Ly, Pierre; Pizzato, Eugenie; Lehmann, Christian H K; Amon, Lukas; Klein, Christophe; Opolon, Paule; Gomperts Boneca, Ivo; Scoazec, Jean-Yves; Hollebecque, Antoine; Malka, David; Ghiringhelli, François; Dudziak, Diana; Berx, Geert; Vereecke, Lars; van Loo, Geert; Kroemer, Guido; Zitvogel, Laurence; Roberti, Maria Paula.
Afiliación
  • Picard M; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.
  • Yonekura S; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
  • Slowicka K; Institut Pasteur, Unit Biology and Genetics of the Bacterial Cell Wall, Paris, France.
  • Petta I; INSERM, Equipe Avenir, Paris, France.
  • Rauber C; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.
  • Routy B; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
  • Richard C; Université Paris-Saclay, Le Kremlin-Bicêtre cedex, France.
  • Iebba V; VIB Center for Inflammation Research, Ghent, Belgium.
  • Tidjani Alou M; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
  • Becharef S; VIB Center for Inflammation Research, Ghent, Belgium.
  • Ly P; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
  • Pizzato E; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.
  • Lehmann CHK; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
  • Amon L; Université Paris-Saclay, Le Kremlin-Bicêtre cedex, France.
  • Klein C; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.
  • Opolon P; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
  • Gomperts Boneca I; Université Paris-Saclay, Le Kremlin-Bicêtre cedex, France.
  • Scoazec JY; Department of Medical Oncology, Center GF Leclerc, Dijon, France.
  • Hollebecque A; Plateform Transfer in Biological Oncology, Dijon, France.
  • Malka D; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
  • Ghiringhelli F; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.
  • Dudziak D; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
  • Berx G; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.
  • Vereecke L; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
  • van Loo G; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.
  • Kroemer G; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
  • Zitvogel L; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.
  • Roberti MP; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
Cell Death Differ ; 28(5): 1532-1547, 2021 05.
Article en En | MEDLINE | ID: mdl-33262469
ABSTRACT
Ileal epithelial cell apoptosis and the local microbiota modulate the effects of oxaliplatin against proximal colon cancer by modulating tumor immunosurveillance. Here, we identified an ileal immune profile associated with the prognosis of colon cancer and responses to chemotherapy. The whole immune ileal transcriptome was upregulated in poor-prognosis patients with proximal colon cancer, while the colonic immunity of healthy and neoplastic areas was downregulated (except for the Th17 fingerprint) in such patients. Similar observations were made across experimental models of implanted and spontaneous murine colon cancer, showing a relationship between carcinogenesis and ileal inflammation. Conversely, oxaliplatin-based chemotherapy could restore a favorable, attenuated ileal immune fingerprint in responders. These results suggest that chemotherapy inversely shapes the immune profile of the ileum-tumor axis, influencing clinical outcome.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias del Colon / Enfermedades del Íleon / Íleon Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cell Death Differ Año: 2021 Tipo del documento: Article País de afiliación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias del Colon / Enfermedades del Íleon / Íleon Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cell Death Differ Año: 2021 Tipo del documento: Article País de afiliación: Francia