Silica-Based Nanoparticles as Drug Delivery Vehicles for Prostate Cancer Treatment.
Chem Rec
; 21(6): 1535-1568, 2021 Jun.
Article
en En
| MEDLINE
| ID: mdl-33320438
ABSTRACT
Prostate cancer (PCa) is one of the most commonly diagnosed cancers and is the fifth common cause of cancer-related mortality in men. Current methods for PCa treatment are insufficient owing to the challenges related to the non-specificity, instability and side effects caused by the drugs and therapy agents. These drawbacks can be mitigated by the design of a suitable drug delivery system that can ensure targeted delivery and minimise side effects. Silica based nanoparticles (SBNPs) have emerged as one of the most versatile materials for drug delivery due to their tunable porosities, high surface area and tremendous capacity to load various sizes and chemistry of drugs. This review gives a brief overview of the diagnosis and current treatment strategies for PCa outlining their existing challenges. It critically analyzes the design, development and application of pure, modified and hybrid SBNPs based drug delivery systems in the treatment of PCa, their advantages and limitations.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
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Sistemas de Liberación de Medicamentos
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Dióxido de Silicio
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Nanopartículas
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Antineoplásicos
Límite:
Humans
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Male
Idioma:
En
Revista:
Chem Rec
Asunto de la revista:
QUIMICA
Año:
2021
Tipo del documento:
Article